ABSTRACT
One of causes coronary heart
disease is hyperlipidemia. Niacin can increase High Density Lipoprotein level
(HDL) that can remove atheroma, that cause coronary heart disease. Rubber seed
tempe contains niacin. The purpose of this study was to investigate the
increasing HDL level after given rubber seed tempe.
This study is true experiment
with pretest-postest control group design as the research plan. Twenty Sprague
Dawley male rat, 2 months were divided into 5 groups by randomized and given
high cholesterol diet during 7 days. Negative control group was no action,
positive control group was given simvastatin 0,1 mg during 10 days, 1,25 mg;
2,5 mg; 5 mg rubber seed tempe were given to research group 1, research group 2,
research group 3 during 10 days. HDL level examination before and after action
was done to know the increasing HDL level.
The result of One Way Anova
test (p=0,000) showed statistical difference each group. The result of Paired T
Test showed statistical difference (p<0,005) for positive control group,
research group 1, research group 3, and showed no statistical difference for negative
control group and research group 2. As a conclusion it was obvious that rubber
seed tempe can increase HDL level.
KEYWORDS : Niacin, HDL,
Rubber Seed Tempe
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